Zegalogue (dasiglucagon)

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What is Zegalogue (dasiglucagon) for?

Zegalogue (dasiglucagon) is a rescue treatment indicated for severe hypoglycemia in adults and children with diabetes aged 6 years and older.^[1]

It is available as an auto-injector or as prefilled syringe, each containing 06mg/0.6mL dasiglucagon.^[1]

How does Zegalogue (dasiglucagon) work?

Severe hypoglycemia occurs when a person’s blood sugar levels are too low to supply the needs of the brain. When this happens, the patient may become confused and unresponsive or have a seizure. In these emergency situations, Zegalogue can be given to increase blood glucose levels rapidly. The active ingredient in Zegalogue, dasiglucagon, is a glucagon receptor agonist. Glucagon increases blood glucose levels by stimulating the breakdown of glycogen, which helps release sugar stored in the liver into the bloodstream.^[2]

Where has Zegalogue (dasiglucagon) been approved?

Zegalogue (dasiglucagon) was approved for the treatment of diabetic people with severe hypoglycemia by:

• The Food and Drug Administration (FDA), USA on March 22, 2021.^[4]

Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Zegalogue (dasiglucagon) taken?

The standard dosage is:^[1]

• 0.6 mg given by injection under the skin (subcutaneous)

The injections should be given in the lower abdomen, buttocks, thigh, or outer upper arm.^[1]

If there has been no response after 15 minutes, the patient may be given another dose.^[1]

Call for emergency medical help or a healthcare provider right away after you have injected Zegalogue (dasiglucagon).^[1]

Zegalogue (dasiglucagon) may affect the way other medicines work, and other medicines may affect how Zegalogue works, so it is important that you inform your doctor about all medicines you take.^[1]

You should not receive Zegalogue (dasiglucagon) if you:^[1]

• Have a tumor called pheochromocytoma in the gland on top of your kidneys (adrenal gland)
• Have a tumor in your pancreas

Complete information about Zegalogue (dasiglucagon) dosage (modifications) and administration can be found in the official prescribing information listed in our references section.1

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Zegalogue (dasiglucagon)?

Common adverse reactions

The most common side effects ( ≥2% of adult and pediatric patients) listed in the prescribing information include:^[1]

• Nausea
• Vomiting
• Headache
• Diarrhea
• Injection site pain

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include:^[1]

• Worsening of hypoglycemia
• Allergic reactions

Use in a specific population

There is no data on the risk of Zegalogue (dasiglucagon) treatment on fetal health. Untreated hypoglycemia in pregnancy can cause complications and may be fatal.^[1]

Before starting with treatment, tell your doctor about all of your medical conditions.^[1]

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.^[1]

References

1. Full prescribing information [FDA]: Zegalogue (dasiglucagon) [PDF]
Zeeland Pharma, Mar 2021

2. Zegalogue Information
Zegalogue.com, cited Aug 2021

3. Zealand Pharma Announces FDA Approval of Zegalogue® (dasiglucagon) injection, for the Treatment of Severe Hypoglycemia in People with Diabetes
Globenewswire.com, Mar 2021